A balanced charged hydrogel with anti-biofouling and antioxidant properties for treatment of irradiation-induced skin injury

Skin injury caused by large doses of ionizing radiation is the common and severe side effect of radiotherapy. However, its therapeutic efficacy is always hindered by early reactive oxygen species generation, repetitive inflammatory microenvironment and bacterial infection risk. Herein, we report an anti-biofouling hydrogel with anti-inflammation and anti-oxidative properties for the treatment of irradiation-induced skin injury. The antibiofouling hydrogel can be achieved by balancing oppositely charged alginate, hyaluronic acid (HA) and polylysine (PLL) at the optimal ratio, which effectively resist protein and bacterial adhesion, and evades immune response. Moreover, curcumin and epigallocatechin gallate (EGCG) can be facially encapsulated and substantially released from the hydrogel. Results showed that the resulting AHP-Cur/EGCG hydrogel can significantly weaken the development of skin injury and accelerate its healing process by alleviating inflammation, scavenging ROS and promoting angiogenesis. Therefore, the findings presented in this work provide an effective strategy for clinical management and treatment of ionizing radiation-induced skin injury.

Automated summary

This study introduces an antibiofouling hydrogel with anti-inflammatory and anti-oxidative properties for the treatment of skin injury caused by ionizing radiation. The hydrogel effectively resists protein and bacterial adhesion, alleviates inflammation, scavenges ROS, and promotes angiogenesis, showing significant potential for clinical management and treatment of radiation-induced skin injury.