Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 129, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2021.112384
Keywords
Methicillin-resistant Staphylococcus aureus; MRSA; Antibacterial; Nanomaterials; Advanced drug delivery; Drug resistance
Categories
Funding
- Indian Council of Medical Research (ICMR), New Delhi, India [35/10/2019-Nano/BMS, 5/13/8/2020/NCD-III]
- University Grants Commission (UGC), New Delhi, India
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Nanotechnology offers potential solutions for improving MRSA treatments, with targeted nanoparticles showing promise in combating drug resistance. The review focuses on nano-engineered carrier systems for antimicrobial agents, highlighting advances and challenges in MRSA treatment while identifying gaps in the literature for future research.
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a threat to global health because of limited treatments. MRSA infections are difficult to treat due to increasingly developing resistance in combination with protective biofilms of Staphylococcus aureus (S. aureus). Nanotechnology-based research revealed that effective MRSA treatments could be achieved through targeted nanoparticles (NPs) that withstand biological films and drug resistance. Thus, the principal aim towards improving MRSA treatment is to advance drug delivery tools, which successfully address the delivery-related problems. These potential delivery tools would also carry drugs to the desired sites of therapeutic action to overcome the adverse effects. This review focused on different types of nano-engineered carriers system for antimicrobial agents with improved therapeutic efficacy of entrapped drugs. The structural characteristics that play an essential role in the effectiveness of delivery systems have also been addressed with a description of recent scientific advances in antimicrobial treatment, emphasizing challenges in MRSA treatments. Consequently, existing gaps in the literature are highlighted, and reported contradictions are identified, allowing for the development of roadmaps for future research.
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