Journal
BIOMATERIALS ADVANCES
Volume 133, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2021.112596
Keywords
Frequency modulation atomic force microscopy; Blood-compatible polymer; Hydration
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Funding
- JSPS KAKENHI [JP19H05720]
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This study utilized frequency modulation atomic force microscopy (FM-AFM) to investigate the interfaces of blood-compatible polymers. It was found that the blood-compatible polymers exhibited thin repulsive layers composed of hydrated polymer chains in water-rich domains, while non-blood-compatible polymers did not show such layers. This discovery is significant for the design of blood-compatible materials.
Blood-compatible materials that do not promote reactions in contact with human blood are required to support emerging medical technologies. The interfaces of poly(2-methoxyethyl acrylate) (PMEA), a blood-compatible polymer, and its analogues were investigated by frequency modulation atomic force microscopy (FM-AFM). The grafted polymers exhibited phase separation into polymer-rich and water-rich domains. Thin repulsive layers of hydrated polymer chains were observed in the water-rich domains of the blood-compatible polymers; on the other hand, such layers were not observed for the non-blood-compatible polymers. We report for the first time that FM-AFM enables characteristic repulsive layers composed of hydrated polymer chains in water-rich domains to be observed, which is a significant design factor for blood-compatible polymers.
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