Journal
MATERIALS LETTERS
Volume 300, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2021.130234
Keywords
Hydroxyapatite microspheres; Simvastatin; Strontium; Sustained-release; Bone repair
Funding
- National Key Research and Development Program of China [2016YFA0201703/2016YFA0201700]
- Key Applied Basic Research Program of Sichuan Province, China [2018JY0031]
- Natural Science Foundation of Tibet Autonomous Region, China [XZ2019ZRG-29]
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The study developed a novel method to prepare Sr- and SIM-loaded hydroxyapatite microspheres for achieving long-term sustained-release of the two drugs. This simple and feasible one-step method can also provide reference for the preparation of other drug-loading microspheres.
The development of multi-functional strontium (Sr) and simvastatin (SIM) loaded biomaterials to promote angiogenesis and osteogenesis is a promising therapeutic strategy. In order to overcome the complex synthesis process, low drug loading and burst release of drug-loaded biomaterials, in this study, we developed a microwave-assisted hydrothermal one-step approach to prepare Sr- and SIM-loaded hydroxyapatite microspheres for achieving long-term sustained-release of Sr and SIM. The developed one-step preparation method can maintain the chemical structure of simvastatin, and the drug loading rate of simvastatin can reach more than 30 wt%. The prepared double-loaded hydroxyapatite microspheres could sustainable release Sr and SIM for more than 35 days. The prepared hydroxyapatite microspheres containing Sr and SIM have a good application prospect in promoting bone formation. This simple and feasible one-step method can also provide reference for the preparation of other drug-loading microspheres.
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