4.6 Article

Synthesis and characterization of PEG coated hollow Fe3O4 magnetic nanoparticles as a drug carrier

Journal

MATERIALS LETTERS
Volume 309, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.matlet.2021.131357

Keywords

Magnetic nanorings; Magnetic nanotubes; Hollow magnetic nanoparticles; Drug loading

Funding

  1. National Natural Science Foundation of China [52072245, 51202146, 81702588]
  2. Natural Science Foundation of Shanghai [17ZR1419700]
  3. Shanghai Engineering Research Center of High-Performance Medical Device Materials [20DZ2255500]

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The hollow Fe3O4 magnetic nanorings and nanotubes have better drug loading capacity and are more suitable for drug carriers compared with nanospheres.
As a drug carrier, the properties of magnetic nanoparticles for drug loading are significant. In this letter, three different shapes of magnetic nanoparticles for drug carrier systems were compared. We synthesized Fe3O4 magnetic nanospheres, nanorings and nanotubes, and plyethylene glycol was used as a surface modifier for drug loading. The structure characterization of three different shapes of Fe3O4 nanoparticles was elucidated by electron microscopy, and the composition was analyzed by Fourier transform infrared. The drug loading status and drug release of the three types of nanoparticles with different shapes were tested by Ultraviolet Spectrophometometer. The results show that the hollow Fe3O4 magnetic nanorings and nanotubes have better drug loading capacity and are more suitable for drug carriers, compared with nanospheres.

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