Journal
MATERIALS LETTERS
Volume 315, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2022.131901
Keywords
Graphene oxide; Metallo-beta-lactamase; Inhibitor
Funding
- JSPS KAKENHI [17K08240]
- Grants-in-Aid for Scientific Research [17K08240] Funding Source: KAKEN
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This study focuses on the enzyme inhibition by graphene oxides (GOs) on Metallo-beta-lactamase (MBL). The results show that reducing the size and oxidation degree of GOs can enhance their inhibitory capacities and alter their inhibition modes.
Metallo-beta-lactamase (MBL) is one of the zinc (II) enzymes that catalyzes hydrolysis of almost all the beta-lactam antibiotics for clinical use. In this study, we have focused on enzyme inhibition by graphene oxides (GOs). We prepared GOs with different sizes, oxidation degrees and functional group positions, and investigated the enzyme inhibition for IMP-1 of MBL using four types of GOs: conventional GO, nano-sized GO (nGO), reduced GO (RGO), and reduced nGO (RnGO). It was demonstrated that reducing the size and oxidation degree of GOs can improve their inhibitory capacities and change their inhibition modes. The results of this study will lead to expand the range of applications of GOs and contribute to further development of MBL inhibitors in the future.
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