Molecularly imprinted polymer-silica nanocomposite based potentiometric sensor for early prostate cancer detection

A novel nanocomposite based on molecularly imprinted polymer (MIP) polymerized over silica nanoparticles (Si) is used for the development of an all-solid-state (ASS) potentiometric sensor for determination of sarcosine, a biomarker for Prostate Cancer (PCa). This MIP-Si sensor has shown high selectivity in phosphate-buffered solution (PBS) and simulated body fluid (SBF). We have obtained a linear response (10(-8) -10(-8) mol/L), with a low detection limit (7.8 x 10(-8 )mol/L) and a quick response time close to 30 s, being stable for at least 150 days. It is corroborated that the sensor is a stable, reproducible, and sensitive biosensing device for PCa detection.

Automated summary

The novel nanocomposite sensor based on MIP polymerized over Si nanoparticles shows high selectivity for the detection of sarcosine as a biomarker for Prostate Cancer. It exhibits stable, reproducible, and sensitive characteristics, making it a reliable biosensing device for PCa detection.