Journal
MATERIALS CHEMISTRY AND PHYSICS
Volume 272, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2021.125018
Keywords
Electrophoretic deposition; Cellulose nanofiber matrix; Drug loading; Biocompatibility; Osteogenesis
Categories
Ask authors/readers for more resources
Multi-component nanocomposite thin films were prepared using cathodic electrophoretic deposition under different isostatic pressures. The samples prepared at high pressure condition showed higher drug loading/releasing and resulted in higher biocompatibility and bio-functionality of osteoblast cells on the thin films.
Multi-component nanocomposite thin films (composed of cellulose nanofiber (CNF), alginate, bioglass nanoparticles (BG NPs) and gentamicin) were prepared by using cathodic electrophoretic deposition (EPD) under different isostatic pressures of 10-2 mbar (LP), atmospheric (AP), and 5 bar (HP). According to thermal gravity analysis, larger amounts of CNF and alginate could be deposited on the surface at the AP condition in comparison with the LP and HP conditions. On the other hand, higher amounts of the BG NPs could be deposited at the LP condition as compared to the other conditions. The drug (gentamicin) loading/releasing of the samples prepared at the HP condition was found to be higher than those of the samples prepared at the AP and LP conditions. The drug-releasing within the HP samples resulted in higher biocompatibility, proliferation, and bio-functionality of osteoblast cells on the thin films. The proposed HP-EPD method can promise new generations of biocompatible drug-loaded thin films with desirable features in upcoming nanomedicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available