Journal
MARINE DRUGS
Volume 20, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/md20020095
Keywords
enteromorpha polysaccharide; anti-inflammatory; diabetic wound healing
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In this study, innovative multifunctional wound dressing materials loaded with anti-inflammatory ingredients were developed and their effectiveness in treating diabetic wounds was demonstrated. The materials were able to accelerate wound healing by inhibiting inflammatory activity, making them a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.
The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.
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