Journal
MARINE DRUGS
Volume 20, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/md20020079
Keywords
marine-derived fungus; Talaromyces mangshanicus; antifungal; antibacterial
Categories
Funding
- National Key R&D Program of China [2018YFC0311000]
- Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA [MBSMAT-2019-06]
- National Natural Science Foundation of China [81973204]
- Research Foundation for Advanced Talents of Beijing Technology and Business University [19008021176]
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Seven new compounds and seven known compounds were isolated from a marine-derived fungus, Talaromyces mangshanicus BTBU20211089, which was isolated from a sediment sample collected from the South China Sea. The new compounds possess a novel carbon skeleton and were tested for their bioactivities against bacteria and fungi.
Seven new compounds, namely talaromanloid A (1), talaromydene (2), 10-hydroxy-8-demethyltalaromydine and 11-hydroxy-8-demethyltalaromydine (3 and 4), talaromylectone (5), and ditalaromylectones A and B (6 and 7), together with seven known compounds were identified from a marine-derived fungus, Talaromyces mangshanicus BTBU20211089, which was isolated from a sediment sample collected from the South China Sea. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D, and 2D NMR techniques. The absolute configurations of 1 and 2 were elucidated by comparing experimental and calculated ECD spectra. Compounds 1, 2, 6, and 7 are new compounds possessing a novel carbon skeleton. Compound 6 is a dimeric molecule of 3 and 9. Compound 7 shared a unique structure of the cyclized dimer of 3 and 4. All the compounds were tested for their bioactivities against Staphylococcus aureus, Escherichia coli, and Candida albicans.
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