Journal
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Volume 35, Issue 1, Pages 87-104Publisher
SPRINGER
DOI: 10.1007/s10334-021-00994-1
Keywords
MRI; Cancer; glucoCEST; DGE MRI; Glucose; CEST; 3-Oxy-methyl-d-glucose
Funding
- National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre (UCLH BRC)
- European Union's Horizon 2020 research and innovation program [667510]
- European Institute for Biomedical Imaging Research (EIBIR)
- External International Advisory Board (EIAB)
- External Data and Safety Monitoring Board (EDSMB)
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This article discusses the importance of advanced medical imaging technology in the early detection of cancer, and the sensitivity of dynamic glucose-enhanced MRI in cancer detection. The GLINT consortium is an important international collaboration project aimed at translating this technology into clinical practice.
Cancer is one of the most devastating diseases that the world is currently facing, accounting for 10 million deaths in 2020 (WHO). In the last two decades, advanced medical imaging has played an ever more important role in the early detection of the disease, as it increases the chances of survival and the potential for full recovery. To date, dynamic glucose-enhanced (DGE) MRI using glucose-based chemical exchange saturation transfer (glucoCEST) has demonstrated the sensitivity to detect both d-glucose and glucose analogs, such as 3-oxy-methyl-d-glucose (3OMG) uptake in tumors. As one of the recent international efforts aiming at pushing the boundaries of translation of the DGE MRI technique into clinical practice, a multidisciplinary team of eight partners came together to form the glucoCEST Imaging of Neoplastic Tumors (GLINT) consortium, funded by the Horizon 2020 European Commission. This paper summarizes the progress made to date both by these groups and others in increasing our knowledge of the underlying mechanisms related to this technique as well as translating it into clinical practice.
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