Dynamic Protein Adsorption-Desorption Analysis of Contact Lenses in a Three-Dimensional-Printed Eye Model

Adsorption of secreted protein on contact lenses is a dynamic and complex behavior. To understand this behavior, we used three-dimensional (3D) printing technology to create an eye model that simulated the anterior segment of the actual human eyeball. In this model, the fluid inlet was connected to a syringe pump to mimic the rate of human tear secretion and the outlet was connected to an ultraviolet-visible (UV-Vis) spectrophotometer. The experimental results revealed that the symmetrical eye model with a 180 degrees inlet-outlet angle was suitable for dynamic analysis of protein adsorption. In this model, protein adsorption was slow and desorption was rapid. The contact lens was soaked in poly(2-methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate) (PMB) to confirm the anti-protein adsorption property of this polymer through dynamic adsorption and desorption eye model analysis.

Automated summary

This study used three-dimensional printing technology to create an eye model that simulated the anterior segment of the human eyeball. The experimental results revealed that a symmetrical eye model with a 180 degree inlet-outlet angle was suitable for dynamic analysis of protein adsorption.