Journal
MACROMOLECULAR RESEARCH
Volume 29, Issue 12, Pages 843-846Publisher
POLYMER SOC KOREA
DOI: 10.1007/s13233-021-9102-8
Keywords
surface modification; magnetic nanoparticles; polyelectrolyte multilayers; bioactive conjugate; antifouling
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Funding
- Chungnam National University fund
- National Research Foundation [NRF-2020R1A2C2009666]
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In this study, we successfully used H-bonding and/or electrostatic force-driven polyelectrolyte multilayer coatings on magnetic colloidal particles to prevent irreversible coagulation and introduce biochemical moieties, enhancing specific cell-magnetic particle interactions. These functional coatings show great potential in bio-applications, including targeted intracellular drug delivery.
In this paper, we used H-bonding and/or electrostatic force-driven polyelectrolyte multilayer (PEM) coatings on the surface of magnetic (paramagnetic and ferromagnetic) colloidal particles to prevent irreversible coagulation and introduce biochemical moieties. Polyacrylamide (PAAm), poly(acrylic acid) (PAA), and a cationic modified cyclodextrin polymer P(beta-CyD) were used for the coating. Through the chemical groups of the PEM coating, the RGD-peptide ligand was introduced on the magnetic particles, which enhanced strong specific cell-magnetic particle interactions. P(beta-CyD)-containing surface-coated magnetic particles also show great potential in cell culture. These functional PEM coatings on magnetic colloidal particles may have great potential in bio-applications including targeted intracellular drug delivery.
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