Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 43, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.202100892
Keywords
drug delivery; fluorescence correlation spectroscopy; polymeric nanocarriers
Categories
Funding
- DFG [SFB 1066]
- Emmy Noether program
- Projekt DEAL
Ask authors/readers for more resources
The use of nanoparticles as carriers for therapeutic agents is promising, and fluorescence correlation spectroscopy is a versatile tool for characterization of these carriers.
The use of nanoparticles as carriers is an extremely promising way for administration of therapeutic agents, such as drug molecules, proteins, and nucleic acids. Such nanocarriers (NCs) can increase the solubility of hydrophobic compounds, protect their cargo from the environment, and if properly functionalized, deliver it to specific target cells and tissues. Polymer-based NCs are especially promising, because they offer high degree of versatility and tunability. However, in order to get a full advantage of this therapeutic approach and develop efficient delivery systems, a careful characterization of the NCs is needed. This review highlights the fluorescence correlation spectroscopy (FCS) technique as a powerful and versatile tool for NCs characterization at all stages of the drug delivery process. In particular, FCS can monitor and quantify the size of the NCs and the drug loading efficiency after preparation, the NCs stability and possible interactions with, e.g., plasma proteins in the blood stream and the kinetic of drug release in the cytoplasm of the target cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available