Targeting macrophages in muscular dystrophies?

Macrophages play an essential role during muscle regeneration. Alteration of their properties is observed in chronic diseases such as degenerative myopathies, where they contribute to muscle fibrosis. Modulation of macrophage inflammatory status represents a relevant therapeutic strategy to improve muscle homeostasis.

Automated summary

Macrophages are crucial for muscle regeneration but their alteration can lead to muscle fibrosis in chronic diseases. Modulation of macrophage inflammatory status is an effective therapeutic strategy for improving muscle homeostasis.