Journal
LUNG CANCER
Volume 160, Issue -, Pages 32-35Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2021.07.020
Keywords
Lung cancer; ALK variants; ALK TKIs; Case report
Categories
Funding
- Shanghai Anticancer Association [SACA-CY19C12]
- Clinical Research Plan of SHDC [SHDC2020CR3025B]
- CSCO-Leading Cancer Research Fund [Y-2019AZZD-0561]
- CSCO-MSD Cancer Research Fund [YMSD2020-0336]
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After treatment with the first-line therapy drug alectinib for ALK-positive non-small-cell lung cancer, a patient rapidly acquired drug resistance, followed by multi-drug resistance and a short survival time.
Alectinib, a highly selective inhibitor of anaplastic lymphoma kinase (ALK), has shown a high response rate and long progression-free survival in primary treatment of ALK-positive non-small-cell lung cancer (NSCLC). De novo resistance or refractory subtype is rare event. Herein, we identify the first case with serial next-generation sequencing (NGS) results that harboured a rare echinoderm microtubule associated protein like 4 gene (EML4) -ALK (breaking site at exon 19) fusion in a lung adenocarcinoma (LUAD) patient who acquired alectinib resistance rapidly (less than 3 months), followed by multi-drug resistance and short survival time.
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