4.7 Article

Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Protective Effect of Vitamin E on Cadmium-Induced Renal Oxidative Damage and Apoptosis in Rats

Jing Fang et al.

Summary: Cadmium is highly toxic to the kidney, while Vitamin E has a protective effect on renal damage and oxidative stress induced by Cadmium by enhancing the antioxidant defense system and inhibiting apoptosis.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

Article Medicine, Research & Experimental

Galangin mitigates iron overload-triggered liver injury: Up-regulation of PPARγ and Nrf2 signaling, and abrogation of the inflammatory responses

Samir A. Salama et al.

Summary: The study demonstrated that galangin has a significant protective effect against iron-induced hepatotoxicity, reducing liver iron content, serum ferritin level, and oxidative stress. Galangin exerts its effects through various mechanisms, including up-regulation of Nrf2, PPAR gamma, and down-regulation of NF-cB signaling pathways.

LIFE SCIENCES (2021)

Article Medicine, Research & Experimental

Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways

Hany H. Arab et al.

Summary: The study found that sitagliptin attenuated testicular injury induced by Cd by modulating the AMPK/mTOR and Nrf2/HO-1 pathways, improving testicular weight, sperm count/motility, sperm abnormalities, and serum testosterone levels, as well as enhancing defective autophagy and suppressing apoptotic events.

LIFE SCIENCES (2021)

Article Biotechnology & Applied Microbiology

Xianling Gubao Capsule Prevents Cadmium-Induced Kidney Injury

Jian Huang et al.

Summary: The study demonstrates that Xianling Gubao Capsule can effectively protect the kidneys from toxic damage by reducing the accumulation of harmful substances and improving cellular conditions.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Environmental Sciences

Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway

Wenxuan Dong et al.

Summary: Cd exposure induces kidney cell injury by inhibiting autophagic flux leading to p62 accumulation and Nrf2 nucleus translocation. Nrf2 nucleus translocation inhibits AMPK phosphorylation, activates the AKT/mTOR signaling, and ultimately results in rPT cell injury.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Oncology

miR-17-5p attenuates kidney ischemia-reperfusion injury by inhibiting the PTEN and BIM pathways

Ming Ma et al.

Summary: The upregulation of miR-17-5p expression appears to protect against kidney ischemia-reperfusion injury by inhibiting apoptosis and autophagy through suppressing PTEN and BIM expression, subsequently upregulating downstream Akt/Beclin1 expression.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Medicine, Research & Experimental

Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling

Hany H. Arab et al.

Summary: The study demonstrates that linagliptin has the potential to mitigate colitis severity in rats by targeting multiple inflammatory pathways and oxidative stress, suggesting its promise for managing IBD.

LIFE SCIENCES (2021)

Article Pharmacology & Pharmacy

Yiqi Jiedu Huayu Decoction Alleviates Renal Injury in Rats With Diabetic Nephropathy by Promoting Autophagy

Chen Xuan et al.

Summary: The study found that YJHD can effectively improve renal function, alleviate renal pathological injury, protect podocytes, and reduce renal fibrosis. The mechanism may be related to the promotion of autophagy, inhibition of the mTOR pathway, and regulation of the PI3K/Akt and AMPK pathways.

FRONTIERS IN PHARMACOLOGY (2021)

Article Endocrinology & Metabolism

Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway

Hong Liu et al.

Summary: Emodin effectively improves renal tissue damage and reduces proteinuria in diabetic nephropathy rats by regulating the AMPK/mTOR-autophagy signaling pathway, suppressing cell apoptosis and enhancing podocyte autophagy.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

Article Medicine, Research & Experimental

Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats

Mohammad H. Abukhalil et al.

Summary: This study demonstrated that galangin has a cardioprotective effect on diabetic rats by improving hyperglycemia, dyslipidemia, heart function, and preventing histopathological changes. Galangin also attenuated cardiac oxidative injury, inflammation, and apoptosis, while boosting antioxidant defenses.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Medicine, Research & Experimental

Activation of AMPK/mTOR-driven autophagy and inhibition of NLRP3 inflammasome by saxagliptin ameliorate ethanol-induced gastric mucosal damage

Hany H. Arab et al.

Summary: The study demonstrated that saxagliptin could protect against ethanol-induced gastric injury by enhancing autophagy, suppressing apoptosis, and inhibiting the NLRP3 inflammasome pathway.

LIFE SCIENCES (2021)

Article Toxicology

Galangin attenuates oxidative stress-mediated apoptosis in high glucose-induced renal tubular epithelial cells through modulating renin-angiotensin system and PI3K/AKT/mTOR pathway

Jie Liao et al.

Summary: In a simulated diabetic nephropathy cell model, it was found that Galangin could alleviate oxidative stress injury in renal tubular epithelial cells induced by high glucose by inhibiting RAS activation, providing insight into the development mechanism of DN.

TOXICOLOGY RESEARCH (2021)

Review Cell Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky et al.

Summary: The guidelines presented in this article aim to assist researchers in selecting and interpreting methods to examine autophagy, as well as to help reviewers provide constructive critiques of reports focused on these processes. It emphasizes that no single assay is perfect for every situation, and multiple techniques may be needed to properly monitor autophagy in different experimental settings. The article also highlights the importance of targeting multiple autophagy-related genes in genetic approaches to block autophagy effectively.

AUTOPHAGY (2021)

Article Chemistry, Multidisciplinary

Protective effects of polydatin and grape seed extract in rats exposed to cadmium

Mustafa Evcimen et al.

DRUG AND CHEMICAL TOXICOLOGY (2020)

Review Biochemistry & Molecular Biology

Autophagy Function and Regulation in Kidney Disease

Gur P. Kaushal et al.

BIOMOLECULES (2020)

Article Chemistry, Medicinal

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy

Xinxu Zhang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

Article Biochemistry & Molecular Biology

Autophagy inhibition-enhanced assembly of the NLRP3 inflammasome is associated with cisplatin-induced acute injury to the liver and kidneys in rats

Xiaoyu Qu et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019)

Article Biochemistry & Molecular Biology

Protective Effects of Fragaria ananassa Extract Against Cadmium Chloride-Induced Acute Renal Toxicity in Rats

Manal F. Elkhadragy et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2018)

Article Cell Biology

Galangin Alleviates Liver Ischemia-Reperfusion Injury in a Rat Model by Mediating the PI3K/AKT Pathway

Yang Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Review Urology & Nephrology

SIRT1 and Kidney Function

Yi Guan et al.

KIDNEY DISEASES (2016)

Review Cell Biology

Self-consumption: the interplay of autophagy and apoptosis

Guillermo Marino et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Urology & Nephrology

Dipeptidyl peptidase IV inhibitor attenuates kidney injury in rat remnant kidney

Kwon Wook Joo et al.

BMC NEPHROLOGY (2013)

Article Pharmacology & Pharmacy

Mechanisms of Cadmium-Induced Proximal Tubule Injury: New Insights with Implications for Biomonitoring and Therapeutic Interventions

Walter C. Prozialeck et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Article Biochemistry & Molecular Biology

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

S. Luo et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Biochemistry & Molecular Biology

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

Ian M. Copple et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Pharmacology & Pharmacy

Metallothionein protection of cadmium toxicity

Curtis D. Klaassen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

Structure-radical scavenging activity relationships of flavonoids

Ameha Seyoum et al.

PHYTOCHEMISTRY (2006)