Journal
LIFE SCIENCES
Volume 287, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.120110
Keywords
Vitamin D; VDR; Immune system; Cancer; Purinergic
Funding
- Fundacao Coordenacao de Aperfeicoamento de Pessoal de Nvel Superior (CAPES-PRINT) [88887.571560/2020-00]
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Vitamin D plays crucial roles in bone health and immune modulation, potentially serving as a useful adjunct in cancer therapy, with the purinergic system identified as a potential treatment target.
For several years, scientists have recognized that vitamin D plays an important role in mineral and bone homeostasis. It was mostly used to treat osteoporosis and rickets in the past decades. Vitamin D has also been discovered to be modulator of the immune system and may play a role in a variety of diseases, including autoimmune diseases, in recent years. Vitamin D interaction with the vitamin D receptor (VDR), which has transcriptional imparts and is displayed on a variety of cell types, including those of the immune system, appears to be accountable for the immune-modulating effects. The action of tumor cells and vitamin D were the first to be investigated, but the spotlight is now on immunologic and purinergic systems. We conducted a systematic search in Pub Med as well as Google scholar for studies written in English. Vitamin D, cancer, purinergic signaling, and immune response were among the search words. Vitamin D has the potential to be a useful coadjuvant in cancer therapy and the purinergic system may be a potential treatment target to cancer therapy, according to our findings.
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