Journal
LIFE SCIENCES
Volume 284, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.119921
Keywords
Ferulic acid; Pharmacological effects; Toxicity; Pharmacokinetics; Derivatives
Funding
- National Nature Science Foundation of China [82074094]
- Xinglin Scholar Research Premotion Project of Chengdu University of TCM [CXTD2018014, QNXZ2018022]
- Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China [2020XSGG002]
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Ferulic acid, a phenolic substance widely found in plants, has been shown to have various biological activities such as antioxidative, anti-inflammatory, anti-apoptotic, and vascular protective effects. Its mechanisms of action involve inhibition of certain signaling pathways and enzymes related to oxidative stress, inflammation, and fibrosis.
Ferulic acid, a kind of phenolic substance widely existing in plants, is an important active component of many traditional Chinese medicines. So far, it has been proved that ferulic acid has a variety of biological activities, especially in oxidative stress, inflammation, vascular endothelial injury, fibrosis, apoptosis and platelet aggregation. Many studies have shown that ferulic acid can inhibit PI3K/AKT pathway, the production of ROS and the activity of aldose reductase. The anti-inflammatory effect of ferulic acid is mainly related to the levels of PPAR gamma, CAM and NF-K B and p38 MAPK signaling pathways. Ferulic acid not only protects vascular endothelium by ERK1/2 and NO/ET-1 signal, but also plays an anti-fibrosis role by TGF-13/Smad and MMPs/TIMPs system. Moreover, ferulic acid has ant-apoptotic and anti-platelet effects. In addition to the pharmacological effects of ferulic acid, its pharmacokinetics and derivatives were also discussed in this paper. This review provides the latest summary of the latest research on ferulic acid.
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