4.7 Article

Maternal high fructose diet exacerbates white adipose tissue thermogenic process in offspring upon exposure to cold temperature

Journal

LIFE SCIENCES
Volume 287, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.120066

Keywords

Metabolic programming; Maternal fructose diet; Beige adipocytes; UCP-1; White adipose tissue

Funding

  1. Agencia Nacional de Promocion de la Ciencia y la Tecnologia [PICT-2017-2334, PICT-2017-2314, PICT-2015-2352]
  2. FPREDM (Switzerland)

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The study found that offspring born to mothers who consumed a fructose-rich diet during pregnancy showed a higher capacity for white adipose tissue (WAT) browning in response to cold exposure in adulthood. However, these offspring exhibited a lower basal thermogenic capacity.
Aim: An adverse endogenous environment during early life predisposes to metabolic disorder development. We previously reported adverse metabolic and adipose tissue effects in adult male rats born to dams fed with a fructose-rich diet (FRD). The aim of this work was to determine the effect of a FRD consumed by the pregnant mother on the white adipose tissue (WAT) browning capacity of male offspring at adulthood. Main methods: Adult S-D male offspring from control (C) and FRD-fed mothers were exposed during one week to a cold stimulus. WAT browning capacity was studied through in vivo and in vitro approaches. Key findings: After cold exposure, WAT browning was higher in fructose-programmed animals as evidenced by an increase in ucp-1 gene expression, protein levels, and higher UCP-1 positive foci. Moreover, pgc1-alpha gene expression was increased. In vitro studies showed a lower adipogenic capacity in cells of prenatally fructoseexposed animals differentiated with a white differentiation cocktail, while a higher ucp-1 expression was noted when their cells were treated with a pro-beige differentiation cocktail. Significance: For the first time we demonstrate that pre-natal fructose exposure predisposes programmed male rats to a higher WAT browning-induced response, under stimulated conditions, despite an apparent lower basal thermogenic capacity. These results should be considered in future studies to generate new therapeutic approaches to deal with adverse programming malnutrition effects.

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