Journal
LEUKEMIA RESEARCH
Volume 111, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2021.106687
Keywords
Plasma cell leukemia; Primary plasma cell leukemia; Secondary plasma cell leukemia; Plasma cell dyscrasia; Multiple myeloma; Circulating plasma cells; Clinical trials; Genomics
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Plasma cell leukemia, whether primary or secondary, is a rare and aggressive blood disorder with poor survival rates despite effective therapies. Recent molecular studies using gene expression profiling and whole exome sequencing have provided new insights into the disease, potentially leading to improved prognosis and treatment strategies.
Plasma cell leukemia is a rare and aggressive plasma cell dyscrasia associated with dismal outcomes. It may arise de novo, primary plasma cell leukemia, or evolve from an antecedent diagnosis of multiple myeloma, secondary plasma cell leukemia. Despite highly effective therapeutics, survival for plasma cell leukemia patients remains poor. Molecular knowledge of plasma cell leukemia has recently expanded with use of gene expression profiling and whole exome sequencing, lending new insights into prognosis and therapeutic development. In this review, we describe the molecular knowledge, clinical characteristics, evidenced-based therapeutic approaches and treatment outcomes of plasma cell leukemia.
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