Journal
LEUKEMIA & LYMPHOMA
Volume 63, Issue 6, Pages 1445-1454Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2022.2030474
Keywords
L-Asparaginase; N- acetylcysteine; liver; pancreas
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This study investigates the effects of N-acetylcysteine (NAC) on liver and pancreatic damage induced by L-asparaginase (L-ASP) in rats. The results indicate that NAC can reduce the damage caused by L-ASP.
In this study, oxidative stress marker (malondialdehyde, MDA) and antioxidant enzymes (glutathione (GSH), catalase (CAT)) levels in the liver and pancreas tissue and the histopathological effects of N-acetylcysteine (NAC) were investigated in L-asparaginase (L-ASP) induced liver and pancreatic damage in rats. Forty male albino rats were divided into four groups. The control group was intraperitoneally injected physiological saline (0.02 mL/g); NAC group was injected NAC (200 mg/kg, five days); L-ASP group was injected single-dose L-ASP (10,000U/kg), and LASP + NAC group was injected NAC for five days following single-dose L-ASP (10,000 U/kg). The surgical operation was performed on all animals on the fifth day. There was no difference between the groups regarding tissue MDA, GSH, and CAT levels (p>.05, for all). In the group receiving NAC after L-ASP, there was a significant improvement in the liver and pancreas damage score than the L-ASP group. NAC was effective in reducing organ damage caused by L-ASP.
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