Synthesis, Antioxidant and Antidiabetic Activity of 1-[(5-Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole

A series of 1-[(5-substituted phenyl)-4, 5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole derivatives (4a-j) have been synthesized by the reaction of 1-(5-substitutedphenyl-1H-tetrazol-1-yl) prop-2-en-1-one (3a-j) with hydrazine hydrate in acetic acid under reflux for 5 h. Structure of the synthesized compounds was established by their spectral data. As a new strategy for alleviating the oxidative damage in diabetes mellitus, a growing interest has been observed in the usage of antioxidants. The synthesized compounds were screened for their in vitro antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging method and in vivo antidiabetic activity by streptozotocin-induced model. Compounds 4b, 4g, 4h and 4j were exhibit prominent antioxidant as well as antidiabetic activity. Compound 4i was exhibit moderate antidiabetic activity.