Journal
LANGMUIR
Volume 38, Issue 3, Pages 927-936Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.1c02093
Keywords
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Funding
- National Key Research and Development Project [2021YFC2100100]
- National Natural Science Foundation of China [22007049]
- Natural Science Foundation of Jiangsu Province [BK20200718, BK20200728]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [20KJB350010]
- Jiangsu Innovation and Entrepreneurship Doctoral Program
- Jiangsu Specially-Appointed Professor Project
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In this study, we successfully encapsulated glucose oxidase and magnetic nanoparticles using amorphous ZIF-90 as a host material, creating a promising enzymatic cascade catalyst.
Integrating nanozymes with natural enzymes to form cascade reactions is one of the most promising ways to develop biocatalysts with versatile performance; however, the applicability of the cascade is typically hampered by the instability of enzymes and the hindrance of mass transfer in the host environment. Utilizing amorphous ZIF-90 (aZIF-90) as a host material, herein, we have reported a one-pot way to encapsulate glucose oxidase (GOx) and magnetic nanoparticles (MNP) to form GOx/MNP@aZIF-90. We reasoned that the amorphous structure of ZIF-90 not only provides a protected environment to confine the cascade reaction but also generates mesopores and internal voids to improve the performance of the enzymatic cascade. The catalytic activity of aZIF-90 was almost 4 times higher than that of crystalline composites, and the residual activity was higher than 80% after being stored for 9 days. This is the first time that GOx and MNP were simultaneously confined in aZIF-90 with mesopores, which suggested that an amorphous metal-organic framework is promising in the development of an enzymatic cascade.
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