Acquired FVII Deficiency and Acute Myeloid Leukemia: A Case Report and Literature Review

Factor VII (FVII) deficiency is the most common among all rare inherited bleeding disorders. However, acquired FVII deficiency (aFVIID) is uncommon. Only few cases in the literature have been reported. Herein, we present a case of an aFVIID associated with acute myeloid leukemia (AML), along with a literature review regarding this condition. A 50 year old Arab male patient was diagnosed with AML at the hematology department of our institution. At admission, coagulation tests showed a prolonged prothrombin time (PT) with a normal activated partial thromboplastin time (aPTT) and a slightly elevated fibrinogen level. Prothrombin complex coagulation factors dosing (PCCFD) revealed a decrease only in FVII levels. The patient, however, did not experience any bleeding. The evolution of the health of the patient was marked by a normalization of PT and FVII levels and complete remission.

Automated summary

Factor VII deficiency is the most common rare inherited bleeding disorder, while acquired FVII deficiency is uncommon. This study presents a case of acquired FVII deficiency associated with AML and reviews the literature on this condition. The patient showed normalization of PT and FVII levels and achieved complete remission.