Serum α-fetoprotein level at treatment completion is a useful predictor of hepatocellular carcinoma occurrence more than one year after hepatitis C virus eradication by direct-acting antiviral treatment

Direct-acting antivirals (DAAs) have recently been developed to treat hepatitis C virus (HCV) infection, and interferon-free DAA treatment has improved liver function of HCV patients. The risk of hepatocellular carcinoma (HCC) occurrence following HCV eradication has been previously reported, but HCC may have been missed following imaging diagnosis before DAA administration in previous studies. Therefore, the present study aimed to identify definite predictors of HCC occurrence >= 1 year after DAA treatment. Among 956 patients receiving DAAs for HCV infection, 567 patients who achieved sustained virologic response with no history of HCC treatment were enrolled in this study between September 2014 and July 2021. The incidence of HCC in HCV-infected patients >= 1 year following DAA treatment, and the predictors contributing to HCC occurrence were identified using clinical characteristics and blood test results. In the present study, 25 patients developed HCC. The incidence of HCC was 1.4%, 3.2%, 4.9% and 6.8% at 2, 3, 4 and 5 years, respectively, from the end of treatment with DAAs. Multivariate logistic analysis revealed serum alpha-fetoprotein level at end of treatment (EOT-AFP) >3.8 ng/ml >= 1 year following treatment with DAAs (HR, 9.7; p < .0001) as an independent factor that may contribute to HCC occurrence following DAA treatment. In conclusion, serum EOT-AFP level may serve an important role in determining the risk of HCC occurrence >= 1 year after DAA treatment. Regular examinations are required even if serum EOT-AFP level is low at treatment completion.

Automated summary

Direct-acting antivirals (DAAs) have improved liver function and increased the risk of hepatocellular carcinoma (HCC) occurrence in HCV-infected patients. Serum alpha-fetoprotein level at end of treatment may serve as an independent factor predicting HCC occurrence >= 1 year after DAA treatment. Regular examinations are recommended even if serum alpha-fetoprotein level is low at treatment completion.