Journal
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
Volume 32, Issue 4, Pages 524-531Publisher
WILEY
DOI: 10.1111/vec.13186
Keywords
canine; glomerular filtration rate; kidney injury; metabolic acidosis; tubulopathy
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This article describes a unique case of profound renal tubular acidosis (RTA) with proximal and distal renal tubular dysfunction in veterinary literature. Importantly, the authors hypothesize that the transient RTA may be a manifestation of acute kidney injury secondary to acute pancreatitis.
Objective To describe the clinical presentation and management of a critically ill dog with profound renal tubular acidosis (RTA) with proximal and distal renal tubular dysfunction. Case Summary A 3-year-old neutered female Border Terrier was presented with frequent regurgitation resulting from acute pancreatitis with severe ileus. Venous acid-base analysis and complete urinalysis confirmed the presence of normal anion gap metabolic acidosis with inappropriately alkaline urine (pH 8), consistent with distal RTA. Urinalysis, urine amino acids, and urinary fractional excretion of electrolytes revealed glycosuria (with normoglycemia), aminoaciduria, and increased fractional excretion of sodium, calcium, and phosphate consistent with generalized proximal renal tubulopathy or Fanconi syndrome. The dog responded well to supportive care and alkaline therapy and made a complete recovery. New or Unique Information Provided To the authors' knowledge, this is the first description of RTA with proximal and distal renal tubular dysfunction in the veterinary literature. Furthermore, the authors hypothesize that the transient RTA was a manifestation of acute kidney injury secondary to acute pancreatitis, the first report of this in the literature.
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