Journal
JOURNAL OF TRAVEL MEDICINE
Volume 28, Issue 8, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jtm/taab190
Keywords
Pfizer-BNT162b2; Moderna-mRNA-1273; S-RBD IgA; S-RBD IgG; immune response
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Funding
- Qatar National Research Fund (a member of Qatar Foundation) [UREP28-173-3-057]
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The study found that individuals with prior infection produced higher levels of antibodies compared to those who were vaccine-naive, especially for individuals vaccinated with BNT162b2.
Background Two mRNA vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, obtained the Emergency Use Listing by WHO for preventing COVID-19. However, little is known about the difference in antibody responses induced by these two mRNA vaccines in naive and previously infected (PI) individuals. Method We investigated the levels of anti-S-RBD (total, IgG and IgA) levels in naive and PI individuals, 1-13 (median = 6) weeks following the second dose of either vaccine. Results in the naive-vaccinated group, the mRNA-1273 vaccine induced significantly higher levels of anti-S-RBD total antibodies (3.5-fold; P < 0.001), IgG (2-fold, P < 0.01) and IgA (2.1-fold, P < 0.001) as compared with the BNT162b2 vaccine. In addition, both vaccines produced significantly higher anti-S-RBD total antibody levels in the PI-group compared with naive-vaccinated group. The PI group elicited a higher level of anti-S-RBD IgG than the naive-BNT162b2 (P = 0.05), but not more than the naive-mRNA-1273 (P = 0.9) group. Interestingly, the PI vaccinated group elicited a comparable level of IgA ratio to the naive-mRNA-1273 group but significantly higher than the naive-BNT162b2 group (1.6-fold, P < 0.001). Conclusion Our results showed that the PI-vaccinated group produces a higher level of antibodies than the naive vaccinated group, particularly for those vaccinated with BNT162b2.
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