Journal
INDIAN JOURNAL OF MEDICAL RESEARCH
Volume 143, Issue -, Pages 696-711Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0971-5916.191927
Keywords
Malaria; Plasmodium falciparum; sexual stage antigens; transmission blocking vaccine
Funding
- Indian Council of Medical Research
- Department of Biotechnology, Government of India
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Transmission blocking malaria vaccines are aimed to block the development and maturity of sexual stages of parasite within mosquitoes. The vaccine candidate antigens (Pfs25, Pfs48/45, Pfs230) that have shown transmission blocking immunity in model systems are in different stages of development. These antigens are immunogenic with limited genetic diversity. Pfs25 is a leading candidate and currently in phase I clinical trial. Efforts are now focused on the cost-effective production of potent antigens using safe adjuvants and optimization of vaccine delivery system that are capable of inducing strong immune responses. This review addresses the potential usefulness, development strategies, challenges, clinical trials and current status of Plasmodium falciparum sexual stage malaria vaccine candidate antigens for the development of transmission-blocking vaccines.
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