Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological malignancies, there are some problems that remain to be resolved. For example, there are high recurrence rates and poor efficacy in solid tumors. In this review, we first briefly describe the metabolic re-editing of T cells and the changes in metabolism during the preparation of CAR-T cells. Furthermore, we summarize the latest developments and newest strategies to improve the metabolic adaptability and antitumor activity of CAR-T cells in vitro and in vivo.

Automated summary

CAR-T cell therapy has shown significant efficacy in treating hematological malignancies, but faces challenges in solid tumor therapy. Researchers have been focusing on improving the metabolic adaptability and antitumor activity of CAR-T cells, leading to some breakthroughs in recent years.