Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume 16, Issue 1, Pages 51-62Publisher
WILEY
DOI: 10.1002/term.3258
Keywords
anti-adhesion; phlorotannins; physical barrier
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Funding
- Ministry of Oceans and Fisheries [20190103]
- National Research Foundation of Korea
- Ministry of Science
- ICT [2019R1A2C1007218]
- Ministry of Education [2021R1A6A1A03039211]
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Findings indicate that CAM films loaded with phlorotannins do not alter their unique characteristics, and show potential in inhibiting inflammatory responses and preventing postoperative peritendinous adhesion.
Peritendinous adhesion mainly occurs between proliferating fibrous tissues and adjacent normal organs after surgery. Many physical barriers are applied to the implanted site to prevent peritendinous adhesion. However, these barriers often trigger inflammatory responses. Therefore, our study sought to develop phlorotannins-loaded cartilage acellular matrix (CAM) films as a physical barrier and investigate their inhibitory effect on inflammatory responses, which are associated with the induction of postoperative peritendinous adhesion (PAA). Our findings indicated that incorporating phlorotannin into the CAM film did not affect its unique characteristics including its thermal and spectroscopic properties. Moreover, the phlorotannins-loaded CAM films suppressed the expression of inflammatory mediators on RAW 264.7 macrophages stimulated using Escherichia coli lipopolysaccharides and exhibited an anti-inflammatory effect when implanted subcutaneously in rats. Therefore, our results highlight the potential of phlorotannins-loaded CAM films as a promising physical barrier to prevent PAA.
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