Contact system activation in disseminated intravascular coagulation: activities of prekallikrein and high-molecular-weight kininogen are significant risk factors

The contact system activation can play a role in microthrombus formation of disseminated intravascular coagulation (DIC). This study investigated whether the activity of prekallikrein and high-molecular-weight kininogen (HMWK) correlated DIC progression. Contact system factors (prekallikrein, HMWK, activated factor XII), coagulation factors (IX, XI, XII) and tissue factor were measured in 140 patients who clinically suspected of having DIC. Prekallikrein and HMWK activity levels showed significant linear relationships with DIC score and antithrombin level, whereas prekallikrein and HMWK antigen levels did not. The activated factor XII, factor XII, factor XI and tissue factor were significant risk factors of overt-DIC. This finding suggests that consumption of prekallikrein and HMWK contributes to microvascular thrombosis in DIC. Measurements of prekallikrein and HMWK activity could be used as potential diagnostic markers for overt-DIC.

Automated summary

This study investigates the relationship between the activation of the contact system and the progression of disseminated intravascular coagulation (DIC). The results show that the activity levels of prekallikrein and high-molecular-weight kininogen (HMWK) are linearly correlated with DIC score and antithrombin level. Additionally, the consumption of prekallikrein and HMWK contributes to the formation of microvascular thrombosis in DIC. Therefore, measurements of prekallikrein and HMWK activity could serve as potential diagnostic markers for the progression of overt-DIC.