4.5 Review

The etiopathogenetic and pathophysiological spectrum of parkinsonism

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

iNPH with parkinsonism: response to lumbar CSF drainage and ventriculoperitoneal shunting

Giovanni Mostile et al.

Summary: The clinical study found that a substantial number of iNPH-P patients showed a noticeable motor response on parkinsonian signs a few days after ELD and over two and a half years after VPS. There were no significant changes in cognitive performances detected during the study.

JOURNAL OF NEUROLOGY (2021)

Review Clinical Neurology

Parkinson's disease and skin

Nicki Niemann et al.

Summary: Skin disorders in patients with Parkinson's disease can be divided into non-iatrogenic and iatrogenic disorders. Recent research has shown that skin plays an important role in studying the pathogenesis, drug discovery, novel stem cell therapies, and diagnostics of Parkinson's disease.

PARKINSONISM & RELATED DISORDERS (2021)

Letter Clinical Neurology

Parkinson's disease after COVID-19

Karim Makhoul et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

Article Clinical Neurology

Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets

Demis A. Kia et al.

Summary: This study utilized bioinformatic tools Coloc and TWAS to analyze PD GWAS data from 2017, identifying gene expression and splicing mechanisms associated with PD risk, further characterized using cell-type specificity and weighted coexpression networks. Results suggest that several candidate genes and pathways are associated with the findings observed in PD GWAS studies.

JAMA NEUROLOGY (2021)

Review Clinical Neurology

Emerging concepts on bradykinesia in non-parkinsonian conditions

Giulia Paparella et al.

Summary: Bradykinesia is a common motor abnormality observed in various neurological diseases not primarily characterized by parkinsonism. The underlying pathophysiology of bradykinesia in these conditions may be related to dysfunction of brain networks. It is suggested that a more accurate and widely used definition of bradykinesia is needed in the context of movement disorders and other neurological conditions.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

Article Clinical Neurology

Coexisting Lewy body disease and clinical parkinsonism in amyotrophic lateral sclerosis

Shelley L. Forrest et al.

Summary: This study found a higher prevalence of clinically relevant LBD pathology in ALS patients compared to the general population, which has implications for clinical and neuropathological diagnoses, as well as the identification of biomarkers.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

Review Medicine, General & Internal

Parkinson's disease

Bastiaan R. Bloem et al.

Summary: Parkinson's disease is a neurodegenerative condition with diverse causes and clinical presentations. Diagnosis is clinically based, and treatment goals vary from person to person, emphasizing the need for personalized management. Currently, there is no therapy to slow down or arrest the progression of Parkinson's disease.

LANCET (2021)

Review Clinical Neurology

Challenges in the diagnosis of Parkinson's disease

Eduardo Tolosa et al.

Summary: Parkinson's disease is the second most common neurodegenerative disease, with efforts being made to accurately diagnose and characterize it, including validation of diagnostic criteria and identification of genetic subtypes. Progress in diagnostic biomarkers has opened up possibilities for earlier identification, recognition of diverse subtypes, and development of novel treatments.

LANCET NEUROLOGY (2021)

Article Clinical Neurology

Clinical Outcome and Striatal Dopaminergic Function After Shunt Surgery in Patients With Idiopathic Normal Pressure Hydrocephalus

Massimiliano Todisco et al.

Summary: This prospective interventional study highlights the pathophysiologic relevance of striatal dopaminergic dysfunction in the motor phenotypic expression of iNPH. Absence of levodopa responsiveness, shunt-responsive parkinsonism, and postsurgery improvement of striatal DAT density are findings that corroborate the notion of a reversible striatal dysfunction in a subset of patients with iNPH.

NEUROLOGY (2021)

Article Genetics & Heredity

Expanding the Spectrum of Movement Disorders Associated With C9orf72 Hexanucleotide Expansions

Carlos Estevez-Fraga et al.

Summary: The study found that HRE expansions in the C9orf72 gene are a major cause of frontotemporal dementia and amyotrophic lateral sclerosis. Among patients carrying this genetic mutation, movement disorders are common, with parkinsonism, tremor, and myoclonus being the most frequently observed manifestations.

NEUROLOGY-GENETICS (2021)

Review Clinical Neurology

Rapidly progressive dementia and Parkinsonism as the first symptoms of dural arteriovenous fistula. The Sapienza University experience and comprehensive literature review concerning the clinical course of 102 patients

Daniele Armocida et al.

Summary: Dementia may be caused by dural arteriovenous fistulas (DAVFs) leading to rapidly progressive dementia (RPD) which often goes undiagnosed. The pathogenesis is not fully understood, but DAVFs should be considered in cases of RPD for proper diagnosis and treatment.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

Article Clinical Neurology

Frequency and Characterization of Movement Disorders in Anti-IgLON5 Disease

Carles Gaig et al.

Summary: Anti-IgLON5 disease is a neurological disorder characterized by a variety of movement disorders, with gait disturbances, generalized chorea, and dystonia being the most common. In addition to movement disorders, patients often experience sleep alterations, bulbar dysfunction, and cognitive impairment.

NEUROLOGY (2021)

Article Clinical Neurology

Movement disorders in systemic autoimmune diseases: Clinical spectrum, ancillary investigations, pathophysiological considerations

Elisa Menozzi et al.

Summary: The recognition and characterization of movement disorders associated with systemic autoimmune diseases is an area that remains largely unexplored, beyond the classic associations such as chorea and antiphospholipid syndrome. However, these movement disorders are mostly treatable and can respond to immunotherapy or dietary modifications. Further research is needed to better understand the clinical features, diagnostic tools, and treatment outcomes in this field.

PARKINSONISM & RELATED DISORDERS (2021)

Article Genetics & Heredity

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

Isabel Alfradique-Dunham et al.

Summary: The study identified multiple PD risk alleles that may modify clinical manifestations and influence PD motor subtypes. The discovery of a novel variant at the STK32B locus suggests a potential overlap between genetic risk for essential tremor and tremor-dominant PD.

NEUROLOGY-GENETICS (2021)

Review Clinical Neurology

Seven Solutions for Neuroprotection in Parkinson's Disease

David Devos et al.

Summary: In the development of neuroprotective drugs for Parkinson's disease (PD), it is important to target specific patients, combine multiple treatments, establish early interventions and improve biomarkers, customize drugs, prioritize repurposed drugs, and adapt preclinical models with translational biomarkers.

MOVEMENT DISORDERS (2021)

Article Clinical Neurology

Striatal Dopamine Deficit and Motor Impairment in Idiopathic Normal Pressure Hydrocephalus

Nicolo Gabriele Pozzi et al.

Summary: Idiopathic normal pressure hydrocephalus patients can exhibit a reduction in striatal dopamine reuptake transporter binding, which correlates with the severity of parkinsonism but not with features of ventriculomegaly or white matter changes. Unlike Parkinson's disease, this dopaminergic deficit in idiopathic normal pressure hydrocephalus is more symmetric and prominent in the caudate nucleus.

MOVEMENT DISORDERS (2021)

Article Geriatrics & Gerontology

Presynaptic dopaminergic function in early-onset Alzheimer's disease: an FP-CIT image study

Hyemin Jang et al.

NEUROBIOLOGY OF AGING (2020)

Review Clinical Neurology

Evolving concepts on bradykinesia

Matteo Bologna et al.

BRAIN (2020)

Editorial Material Clinical Neurology

A case of GFAP-astroglial autoimmunity presenting with reversible parkinsonism

Anna Tomczak et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Review Clinical Neurology

Parkinson disease and the immune system - associations, mechanisms and therapeutics

Eng-King Tan et al.

NATURE REVIEWS NEUROLOGY (2020)

Article Clinical Neurology

Parkinson's disease: etiopathogenesis and treatment

Joseph Jankovic et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

Article Clinical Neurology

Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis

Rangariroyashe H. Chipika et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

Editorial Material Clinical Neurology

Stem Cells: Scientific and Ethical Quandaries of a Personalized Approach to Parkinson's Disease

Joseph Jankovic et al.

MOVEMENT DISORDERS (2020)

Article Clinical Neurology

Gaps, Controversies, and Proposed Roadmap for Research in Normal Pressure Hydrocephalus

Alfonso Fasano et al.

MOVEMENT DISORDERS (2020)

Review Geriatrics & Gerontology

Catecholamines in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Xiongfeng Pan et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

New Insights into Immune-Mediated Mechanisms in Parkinson's Disease

Jolene Su Yi Tan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Clinical Neurology

Sleep disorders in autoimmune encephalitis

Amaia Munoz-Lopetegi et al.

LANCET NEUROLOGY (2020)

Review Biochemistry & Molecular Biology

Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease

Chrysoula Marogianni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Clinical Neurology

Toxin-Induced Parkinsonism

Steven McKnight et al.

NEUROLOGIC CLINICS (2020)

Article Clinical Neurology

Apathy in Alzheimer's Disease Correlates with the Dopamine Transporter Level in the Caudate Nuclei

Niki Udo et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA (2020)

Review Clinical Neurology

Movement Disorders and Renal Diseases

Suvorit S. Bhowmick et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2020)

Review Clinical Neurology

Movement Disorders in Metabolic Disorders

Jose Luiz Pedroso et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2019)

Article Clinical Neurology

Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer's disease

Bernard J. Hanseeuw et al.

ALZHEIMERS RESEARCH & THERAPY (2019)

Review Clinical Neurology

Inflammation, Infectious Triggers, and Parkinson's Disease

Elisa Caggiu et al.

FRONTIERS IN NEUROLOGY (2019)

Article Clinical Neurology

Changing views of the pathophysiology of Parkinsonism

Thomas Wichmann

MOVEMENT DISORDERS (2019)

Review Geriatrics & Gerontology

Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

Xiongfeng Pan et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Clinical Neurology

Infectious Etiologies of Parkinsonism: Pathomechanisms and Clinical Implications

Nattakarn Limphaibool et al.

FRONTIERS IN NEUROLOGY (2019)

Review Biochemistry & Molecular Biology

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Ruby Macdonald et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

Article Clinical Neurology

Localizing parkinsonism based on focal brain lesions

Juho Joutsa et al.

BRAIN (2018)

Article Clinical Neurology

Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study

Maryse Feron et al.

JOURNAL OF NEUROLOGY (2018)

Review Clinical Neurology

Autoimmune and paraneoplastic movement disorders: An update

Jose Fidel Saizabal-Carvallo et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2018)

Article Clinical Neurology

Parkinsonian symptoms in normal pressure hydrocephalus: a population-based study

Karin Molde et al.

JOURNAL OF NEUROLOGY (2017)

Article Clinical Neurology

Structural MRI correlates of amyotrophic lateral sclerosis progression

Joe Senda et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

Article Neurosciences

Parkinson's Disease Is Not Simply a Prion Disorder

James Surmeier et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Clinical Neurology

18F-fallypride PET-CT of dopamine D2/D3 receptors in patients with sporadic amyotrophic lateral sclerosis

Xiaoling Fu et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Review Clinical Neurology

Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration

Alberto J. Espay et al.

ANNALS OF NEUROLOGY (2017)

Article Clinical Neurology

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

Aree Witoelar et al.

JAMA NEUROLOGY (2017)

Review Clinical Neurology

Failing as doorman and disc jockey at the same time: Amygdalar dysfunction in Parkinson's disease

Nico J. Diederich et al.

MOVEMENT DISORDERS (2016)

Review Clinical Neurology

Atypical parkinsonism - new advances

Maria Stamelou et al.

CURRENT OPINION IN NEUROLOGY (2016)

Review Multidisciplinary Sciences

How neuroinflammation contributes to neurodegeneration

Richard M. Ransohoff

SCIENCE (2016)

Article Clinical Neurology

Postencephalitic parkinsonism and selective involvement of substantia nigra in childhood

Ibtihel Rebai et al.

BRAIN & DEVELOPMENT (2015)

Review Clinical Neurology

Vascular Parkinsonism: Deconstructing a Syndrome

Joaquin A. Vizcarra et al.

MOVEMENT DISORDERS (2015)

Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

Review Clinical Neurology

Vascular parkinsonism-characteristics, pathogenesis and treatment

Amos D. Korczyn

NATURE REVIEWS NEUROLOGY (2015)

Article Clinical Neurology

Basal ganglia pathology in ALS is associated with neuropsychological deficits

Judith Machts et al.

NEUROLOGY (2015)

Article Clinical Neurology

Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease

John M. Woulfe et al.

PARKINSONISM & RELATED DISORDERS (2014)

Review Geriatrics & Gerontology

Is dopamine involved in Alzheimer's disease?

Alessandro Martorana et al.

FRONTIERS IN AGING NEUROSCIENCE (2014)

Review Clinical Neurology

The cerebellum in Parkinson's disease

Tao Wu et al.

BRAIN (2013)

Review Clinical Neurology

Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome

Jose Fidel Baizabal-Carvallo et al.

JOURNAL OF NEURAL TRANSMISSION (2013)

Article Clinical Neurology

Parkinson's disease-like midbrain hyperechogenicity is frequent in amyotrophic lateral sclerosis

Panteha Fathinia et al.

JOURNAL OF NEUROLOGY (2013)

Review Clinical Neurology

Movement disorders in multiple sclerosis and other demyelinating diseases

Raja Mehanna et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2013)

Correction Clinical Neurology

Movement disorders in cerebrovascular disease (vol 12, pg 597, 2013)

R. Mehanna et al.

LANCET NEUROLOGY (2013)

Article Clinical Neurology

Basal ganglia involvement in amyotrophic lateral sclerosis

Peter Bede et al.

NEUROLOGY (2013)

Review Clinical Neurology

Movement disorders in cerebrovascular disease

Raja Mehanna et al.

LANCET NEUROLOGY (2013)

Article Clinical Neurology

Parkinson-like features in ALS with predominant upper motor neuron involvement

Carla D'Ascenzo et al.

AMYOTROPHIC LATERAL SCLEROSIS (2012)

Review Clinical Neurology

Movement disorders in autoimmune diseases

Jose Fidel Baizabal-Carvallo et al.

MOVEMENT DISORDERS (2012)

Article Clinical Neurology

Nigrostriatal dysfunction in patients with amyotrophic lateral sclerosis and parkinsonism

Hee Kyung Park et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2011)

Review Clinical Neurology

Milestones in Research on the Pathophysiology of Parkinson's Disease

Thomas Wichmann et al.

MOVEMENT DISORDERS (2011)

Article Biophysics

1H MRS of basal ganglia and thalamus in amyotrophic lateral sclerosis

Khema R. Sharma et al.

NMR IN BIOMEDICINE (2011)

Article Clinical Neurology

Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone

S. Saidha et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2010)

Review Biochemistry & Molecular Biology

Viral parkinsonism

Haeman Jang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Editorial Material Clinical Neurology

PARKINSONISM IN HIV-INFECTED PATIENTS ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY

Stephen Tisch et al.

NEUROLOGY (2009)

Article Clinical Neurology

Parkinsonism and multiple sclerosis - Is there association?

Barbara Barun et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2008)

Article Clinical Neurology

Shunt-responsive parkinsonism and reversible white matter lesions in patients with idiopathic NPH

Ichiro Akiguchi et al.

JOURNAL OF NEUROLOGY (2008)

Article Clinical Neurology

Movement disorders in multiple sclerosis: causal or coincidental association?

V. Nociti et al.

MULTIPLE SCLEROSIS JOURNAL (2008)

Article Clinical Neurology

Neuroimaging of Infections of the Central Nervous System

Oliver Kastrup et al.

SEMINARS IN NEUROLOGY (2008)

Review Clinical Neurology

Parkinson's disease: a dual-hit hypothesis

C. H. Hawkes et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2007)

Article Clinical Neurology

A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis

Peter Valkovic et al.

MOVEMENT DISORDERS (2007)

Article Clinical Neurology

Tau and α-synuclein brainstem pathology in Alzheimer disease:: relation with extrapyramidal signs

Johannes Attems et al.

ACTA NEUROPATHOLOGICA (2007)

Review Clinical Neurology

Circuits and circuit disorders of the basal ganglia

Mahlon R. DeLong et al.

ARCHIVES OF NEUROLOGY (2007)

Article Rheumatology

Steroid-reversible parkinsonism as presentation of polymyalgia rheumatica

Pieranna Fietta et al.

CLINICAL RHEUMATOLOGY (2006)

Review Clinical Neurology

The diagnosis of Parkinson's disease

E Tolosa et al.

LANCET NEUROLOGY (2006)

Article Clinical Neurology

Parkinsonism following striatal infarcts: incidence in a prospective stroke unit cohort

C Peralta et al.

JOURNAL OF NEURAL TRANSMISSION (2004)

Article Clinical Neurology

Decreased nigral neuromelanin in Alzheimer's disease

MG Reyes et al.

NEUROLOGICAL RESEARCH (2003)

Article Clinical Neurology

Parkinsonism as a manifestation of multiple sclerosis

S Folgar et al.

MOVEMENT DISORDERS (2003)

Article Clinical Neurology

Progression of parkinsonian signs in Alzheimer's disease

RS Wilson et al.

NEUROLOGY (2000)