Novel Schiff base (E)-2-((4-chloro-3-nitrophenylimino)(phenyl) methyl)-5-methoxyphenol and Mixed Ligand Complexes of Mn(II), Fe(III), Co(II), Ni(II) and Cu(II): synthesis, structure elucidation and potency study as antibacterial, antimalarial, antioxidant, antidibetic and anticancer agents

Novel Schiff Base (E)-2-((4-chloro-3-nitrophenylimino)(phenyl)methyl)-5-methoxyphenol (S-1) synthesized by condensing 2-hydroxy-4-methoxy benzophenone and 4-chloro-3-nitroaniline in ethanol and used for synthesis of five new mixed ligand complexes of Mn(II) Fe(III), Co(II), Ni(II), and Cu(II). The synthesized Schiff base ligand (S-1) has been characterized by IR, UV-Visible, H-1-NMR, C-13-NMR spectra and all the synthesized complexes were characterized by elemental analysis, IR, electronic, thermal methods (TGA-DTA), Powder XRD analysis, magnetic susceptibility and molar conductivity measurements. All the complexes were proposed to have octahedral geometry. All the synthesized compounds were screened for their antimicrobial, antidibetic, antioxidant, antimalarial and anticancer activity. The obtained results indicated towards potential of these complexes as antimalarial and antioxidant agents. [GRAPHICS] .

Automated summary

A novel Schiff base ligand and five mixed metal complexes were synthesized and characterized, with potential antimalarial and antioxidant activities demonstrated in the bioassays.