Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin

The complex and intriguing structures of the antibiotics amycolamicin and kibdelomycin are herein confirmed through total synthesis. Careful titration of the synthetic products reveals that kibdelomycin is the salt form of amycolamicin. This synthesis employs a highly convergent strategy, which provides a modular approach for further SAR studies of this class of antibiotics.

Automated summary

The complex structures of antibiotics amycolamicin and kibdelomycin are confirmed through total synthesis, with kibdelomycin identified as the salt form of amycolamicin. The synthesis employs a convergent strategy, providing a modular approach for further SAR studies of this antibiotic class.