4.8 Article

BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N-nitrosourea-producing enzyme SznF

Molly J. McBride et al.

Summary: The study identified the crucial role of SznF in the biosynthesis of streptozotocin, revealing the binding of two iron cofactors and addressing previous uncertainties about the cofactors. During the cofactor (dis)assembly process, dynamic changes in the core helix were observed, and an unexpected glutamate ligand was found to be involved.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Biosynthesis of fluopsin C, a copper-containing antibiotic from Pseudomonas aeruginosa

Jon B. Patteson et al.

Summary: The study reveals that Pseudomonas aeruginosa is able to synthesize a small-molecule copper complex, fluopsin C, in response to elevated copper concentrations, which serves as a broad-spectrum antibiotic. The pathway involves five enzymes and suggests a common role for fluopsin C in the copper stress response among various bacteria, highlighting its potential as an antibiotic against other microbes.

SCIENCE (2021)

Article Chemistry, Multidisciplinary

A Mononuclear Non-heme Iron(III)-Peroxo Complex with an Unprecedented High O-O Stretch and Electrophilic Reactivity

Wenjuan Zhu et al.

Summary: In this study, a mononuclear non-heme iron(III)-peroxo complex was synthesized and characterized, showing high nu(O-O) value and unprecedented electrophilic reactivity in oxidation reactions. Various spectroscopic techniques confirmed the unique properties of the complex, including its H atom abstraction and O atom transfer reactivity. Additionally, interesting observations were made in the oxidation of benzaldehyde derivatives, indicating the complex's potential in various oxidation reactions.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Multidisciplinary Sciences

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

Tai L. Ng et al.

NATURE (2019)

Article Multidisciplinary Sciences

Discovery of a pathway for terminal-alkyne amino acid biosynthesis

J. A. Marchand et al.

NATURE (2019)

Article Chemistry, Multidisciplinary

Oxidative Decarboxylase UndA Utilizes a Dinuclear Iron Cofactor

Olivia M. Manley et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Multidisciplinary

Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA

Bo Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Multidisciplinary

Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme

Cheng-Ping Yu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Chemistry, Multidisciplinary

Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase Cmll

Andrew J. Jasniewski et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Biochemistry & Molecular Biology

Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

Cory J. Knoot et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2016)

Article Chemistry, Multidisciplinary

An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway

Thomas M. Makris et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Chemistry, Multidisciplinary

Decarboxylation of Fatty Acids to Terminal Alkenes by Cytochrome P450 Compound I

Job L. Grant et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Multidisciplinary Sciences

Structure of the key species in the enzymatic oxidation of methane to methanol

Rahul Banerjee et al.

NATURE (2015)

Article Biotechnology & Applied Microbiology

New gene responsible for para-aminobenzoate biosynthesis

Yasuharu Satoh et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2014)

Article Multidisciplinary Sciences

Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase

Zhe Rui et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Chemistry, Multidisciplinary

Substrate-Triggered Addition of Dioxygen to the Diferrous Cofactor of Aldehyde-Deformylating Oxygenase to Form a Diferric-Peroxide Intermediate

Maria E. Pandelia et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Biochemistry & Molecular Biology

Flavoenzymes: Versatile catalysts in biosynthetic pathways

Christopher T. Walsh et al.

NATURAL PRODUCT REPORTS (2013)

Article Multidisciplinary Sciences

Four-electron oxidation of p-hydroxylaminobenzoate to p-nitrobenzoate by a peroxodiferric complex in AurF from Streptomyces thioluteus

Ning Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O-2 with a nonheme diiron center

Van V. Vu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis

Yoo Seong Choi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Chemistry, Multidisciplinary

Characterization of the arene-oxidizing intermediate in ToMOH as a diiron(III) species

Leslie J. Murray et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biochemistry & Molecular Biology

Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

Danica P. Galonic et al.

NATURE CHEMICAL BIOLOGY (2007)

Review Chemistry, Multidisciplinary

Direct hydrogen-atom abstraction by activated bleomycin: An experimental and computational study

A Decker et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

Article Multidisciplinary Sciences

SyrB2 in syringomycin E biosynthesis is a nonherne FeII α-ketoglutarate- and O2-dependent halogenase

FH Vaillancourt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Chemistry, Multidisciplinary

Reactions of the peroxo intermediate of soluble methane monooxygenase hydroxylase with ethers

LG Beauvais et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Biochemistry & Molecular Biology

Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis

R Schwarzenbacher et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)