Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis

This Article describes the development of a decarbonylative Pd-catalyzed aryl-fluoroalkyl bond-forming reaction that couples fluoroalkylcarboxylic acid-derived electrophiles [RFC(O)X] with aryl organometallics (Ar-M'). This reaction was optimized by interrogating the individual steps of the catalytic cycle (oxidative addition, carbonyl de-insertion, transmetalation, and reductive elimination) to identify a compatible pair of coupling partners and an appropriate Pd catalyst. These stoichiometric organometallic studies revealed several critical elements for reaction design. First, uncatalyzed background reactions between RFC(O)X and Ar-M' can be avoided by using M' = boronate ester. Second, carbonyl de-insertion and Ar-R-F reductive elimination are the two slowest steps of the catalytic cycle when R-F = CF3. Both steps are dramatically accelerated upon changing to R-F = CHF2. Computational studies reveal that a favorable F2C-H center dot center dot center dot X interaction contributes to accelerating carbonyl de-insertion in this system. Finally, transmetalation is slow with X = difluoroacetate but fast with X = F. Ultimately, these studies enabled the development of an (SPhos)Pd-catalyzed decarbonylative difluoromethylation of aryl neopentylglycol boronate esters with difluoroacetyl fluoride.

Automated summary

This article describes the development of a decarbonylative Pd-catalyzed aryl-fluoroalkyl bond-forming reaction. By optimizing the individual steps of the catalytic cycle to identify compatible coupling partners and an appropriate Pd catalyst, an efficient method for decarbonylative difluoromethylation of aryl neopentylglycol boronate esters with difluoroacetyl fluoride was achieved.