Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 143, Issue 50, Pages 21241-21245Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c11266
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Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [Ba 1372/23, Ba 1372/24, TRR 325 (444632635)]
- Emmy Noether fellowship - DFG [Sto 1175/3]
- Fonds der Chemischen Industrie
- Leibniz Supercomputing Centre
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A photochemical deracemization reaction of 5-substituted 3-phenylimidazolidine-2,4-diones (hydantoins) is reported using a chiral diarylketone catalyst. Mechanistic evidence suggests the reaction occurs through selective hydrogen atom transfer, converting substrate enantiomers into product enantiomers.
A photochemical deracemization of 5-substituted 3-phenylimidazolidine-2,4-diones (hydantoins) is reported (27 examples, 69%-quant., 80-99% ee). The reaction is catalyzed by a chiral diarylketone which displays a two-point hydrogen bonding site. Mechanistic evidence (DFT calculations, radical clock experiments, H/D labeling) suggests the reaction to occur by selective hydrogen atom transfer (HAT). Upon hydrogen binding, one substrate enantiomer displays the hydrogen atom at the stereogenic center to the photoexcited catalyst allowing for a HAT from the substrate and eventually for its conversion into the product enantiomer. The product enantiomer is not processed by the catalyst and is thus enriched in the photostationary state.
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