Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 85, Issue 4, Pages 841-846Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2021.06.010
Keywords
aging; biopsies; histopathology; melanoma; melanoma pandemic; overdiagnosis; public health; skin cancer screenings; ultraviolet exposure
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Melanoma incidence has increased since the 1970s, while melanoma-specific mortality has remained stable. Factors contributing to the rise in incidence include an aging population, ultraviolet exposure, increased skin biopsies, skin cancer screenings, and histopathologic criteria.
Background: Melanoma is one of the most commonly diagnosed malignancies in the United States and is responsible for the majority of deaths from skin cancer. Objective: Since the 1970s, the incidence of melanoma has risen appreciably while melanoma-specific mortality has remained stable. This has raised a debate about potential overdiagnosis of melanoma. Herein, we review temporal trends in melanoma incidence and mortality and explore factors that may contribute to observed trends, including an aging population in the United States, ultraviolet exposure, increased numbers of biopsies by dermatologists and physician extenders, skin cancer screenings, histopathology criteria, and historic underdiagnosis. Additionally, we discuss melanoma overdiagnosis and the extent to which it may contribute to current trends. Methods: The literature was reviewed. Results: Several factors may contribute to an increased incidence of melanoma, including an aging population, ultraviolet exposure, increased skin biopsies, skin cancer screenings, histopathologic criteria, historic underdiagnosis, and current overdiagnosis. Limitations: Further studies are required to determine exactly which tumors are being overdiagnosed, and how to improve patient outcomes with adjustment to physician's practice. Conclusion: The rise in the incidence of melanoma observed since the 1970s is likely multifactorial.
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