Supercritical CO2 impregnation of caffeine in biopolymer films to produce anti-cellulite devices

The present work focuses on the production of topical anti-cellulite devices through a supercritical one-step process consisting of the polymer foaming and impregnation of caffeine into PLA/PBAT/CaCO3 films to obtain a biocompatible and biodegradable patch. Field Emission Scanning Electron Microscopy analysis revealed that porosities were formed in the polymeric support when in contact with the supercritical CO2. Atomic force microscopy revealed the presence of caffeine on the polymer surface in the form of needles. The impregnation kinetics determined at 17.0 MPa showed an increase in caffeine loadings with the contact time (up to 16.5% and 23.0% wcaffeine/wfilm at 40 degrees C and 35 degrees C, respectively), corresponding to higher caffeine loadings than the ones contained in commercial products (about 3%). The release of caffeine was simulated by UV-vis spectropho-tometry: pure caffeine dissolved instantly in the dissolution medium, whereas its release was prolonged up to 2 days when it was impregnated within the PLA/PBAT/CaCO3 film.

Automated summary

This study focused on producing topical anti-cellulite devices using a supercritical one-step process that involved polymer foaming and impregnation of caffeine into PLA/PBAT/CaCO3 films to create a biocompatible and biodegradable patch. The results showed that porosities were formed in the polymeric support when in contact with supercritical CO2, and caffeine was found in needle-like forms on the polymer surface. The impregnation kinetics revealed an increase in caffeine loadings with contact time, resulting in extended release time of up to 2 days.