One-pot two-step mechanochemical synthesis of arylsulfonyl 4H-pyrans

In this paper, a simple and environment-friendly protocol was developed for the synthesis of arylsulfonyl 4H-pyrans via L-proline-catalyzed one-pot two-step reaction of aromatic aldehyde with phenylsulphonyl acetonitrile and dimedone under ball-milling conditions. Environmental acceptability, wide substrate scope, low cost and operational simplicity are the key features of this method.

Automated summary

A simple and environmentally friendly protocol was developed for the synthesis of arylsulfonyl 4H-pyrans through the one-pot two-step reaction of aromatic aldehyde with phenylsulphonyl acetonitrile and dimedone catalyzed by L-proline under ball-milling conditions. The key features of this method are its environmental acceptability, wide substrate scope, low cost, and operational simplicity.