Journal
JOURNAL OF RAMAN SPECTROSCOPY
Volume 53, Issue 2, Pages 247-255Publisher
WILEY
DOI: 10.1002/jrs.6275
Keywords
background subtraction; fluorescence background; iteratively reweighted penalized least squares; mathematical processing of spectra; Raman spectroscopy
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A novel adaptive noise model based on iteratively reweighted penalized least squares (ANM-IRPLS) method is proposed for Raman spectrum baseline correction, offering better results in background removal compared to existing methods.
The spectral analysis depends heavily on unwanted signals, such as the fluorescent background from the samples or other interfering components. A number of mathematical algorithms have been proposed to remove the background of Raman spectra. However, these methods require the selection of appropriate parameters to correct the of Raman spectra baseline. In this paper, we propose a method of adaptive noise model based on iteratively reweighted penalized least squares (ANM-IRPLS) for Raman spectrum baseline correction. The algorithm was applied to various artificial spectra containing real forms of baselines and characteristic Raman peaks and then to the spectra of real drug samples with fluorescence obtained on a device equipped with a 532-nm laser with a resolution of 15 cm(-1). The modeling results showed that the proposed ANM-IRPLS baseline correction method allows for better results in background removal than the airPLS. For real Raman spectra processed by the ANM-IRPLS method, it is shown that the algorithm handles a complex background well, while maintaining the characteristic Raman signal features, such as a wide water peak for aqueous solutions.
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