Journal
IMMUNOLOGY LETTERS
Volume 170, Issue -, Pages 42-51Publisher
ELSEVIER
DOI: 10.1016/j.imlet.2015.12.005
Keywords
Innate immunity; Cytokines
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Funding
- Academy of Finland
- Jane and Aatos Erkko Foundation
- Sigrid Juselius Foundation
- Tampere Tuberculosis Foundation
- Tampere Graduate Program in Biotechnology and Biomedicine
- Competitive State Research Financing of the Tampere University Hospital
- Competitive State Research Financing of the Oulu University Hospital
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Cytokines are a large and diverse group of small proteins that can affect many biological processes, but most commonly cytokines are known as mediators of the immune response. In the event of an infection, cytokines are produced in response to an immune stimulus, and they function as key regulators of the immune response. Cytokines come in many shapes and sizes, and although they vary greatly in structure, their functions have been well conserved in evolution. The immune signaling pathways that respond to cytokines are remarkably conserved from fly to man. Therefore, Drosophila melanogaster, provides an excellent platform for studying the biology and function of cytokines. In this review, we will describe the cytokines and cytokine-like molecules found in the fly and discuss their roles in host immunity. (C) 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
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