Preparation and validation of [Ga-67]Ga-phytate kit and Monte Carlo dosimetry: an effort toward developing an impressive lymphoscintigraphy tracer

Radiocolloides are essential for the detection of metastatic lymph nodes in breast cancer. In this study [Ga-67]Ga-phytate, as an long-lived alternative for [Tc-99m]Tc-radiocolloids was prepared. Standard labeling conditions for [Ga-67]Ga-phytate preparation (95-100 degrees C, 30 min, 0.5 mg phytic acid, aqueous solutions) has been adopted (radiochemical purity: > 98 +/- 2% ITLC, specific activity: 0.9-1.1 GBq/mmol). The complex is mainly cleared from the blood pool through the liver by hepatic system (> 90%) and a small percentage (< 7-8%) through the kidneys by renal excretion. Dosimetric simulations showed that the final radiopharmaceutical doses are safe for clinical administrations.

Automated summary

Radiocolloides are essential for detecting metastatic lymph nodes in breast cancer. In this study, a long-lived alternative for radiocolloids was prepared and found to be safe for clinical use.