Journal
JOURNAL OF PUBLIC HEALTH
Volume 43, Issue -, Pages 43-48Publisher
OXFORD UNIV PRESS
DOI: 10.1093/pubmed/fdab239
Keywords
corona virus disease 2019; COVID-19; Pakistan; severity; treatments
Categories
Funding
- Global Health Development (GHD)
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The study found that in patients with severe/critical COVID-19, age over 60, presence of hypertension, heart disease, kidney disease, and late admission (over 5 days) were significant predictors of mortality. The study highlights the importance of timely provision of appropriate medical interventions in controlling COVID-19-related mortality.
Background Inadvertent delays in access to appropriate therapeutic interventions in high-risk group coronavirus disease 2019 (COVID-19) patients contribute to mortality in patients with severe/critical disease presentation. Objectives The aim of this study was to determine the effect of timely admission to the hospital on mortality of patients with severe/critical COVID-19. Another secondary aspect of this study was to observe the efficacy of time-dependent use of corticosteroids on mortality of critical/severe COVID-19 patients. Methods Clinical data of 659 patients with severe/critical COVID-19, admitted to four major tertiary care hospitals from the Islamabad-Rawalpindi region of Pakistan was retrospectively collected from a period February-August 2020. Multivariate logistic regression analysis was carried out to determine the predictors of mortality in severe/critical COVID-19 patients. Results Out of a total of 659 patients, 469 (71.2%) patients died. Age > 60 years, presence of hypertension, heart disease and kidney disease along with late admission (>5 days) were significant predictors of mortality in patients with severe/critical COVID-19. Conclusions The study highlights the importance of well-timed provision of appropriate medical interventions control COVID-19-associated mortality.
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