Journal
JOURNAL OF PROTEOME RESEARCH
Volume 21, Issue 3, Pages 560-589Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.1c00851
Keywords
metabolic profiling; symbiotic; host-microbial cometabolism; osmolyte; trimethylamine; trimethylamine N-oxide; cardiovascular disease; FMO3
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Funding
- Department of Jobs, Tourism, Science and Innovation, Government of Western Australian through the Premier's Science Fellowship Program
- Australian Research Council through the ARC Laureate Fellowship Program
- Spinnaker Health Research Foundation, WA
- McCusker Foundation, WA
- Western Australian State Government
- Medical Research Future Fund
- National Institute for Health Research Biomedical Research Centre (BRC)
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Trimethylamine (TMA) and its N-oxide (TMAO) play important roles in evolutionary biology and diverse biochemical functions, including cell signaling. The significance of TMA and TMAO extends beyond cardiovascular disease risk, encompassing multiple biological processes.
Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote organisms as well as in the environment, reflecting their fundamental importance in evolutionary biology, and their diverse biochemical functions. Both metabolites have multiple biological roles including cell-signaling. Much attention has focused on the significance of serum and urinary TMAO in cardiovascular disease risk, yet this is only one of the many facets of a deeper TMA-TMAO partnership that reflects the significance of these metabolites in multiple biological processes spanning animals, plants, bacteria, and fungi. We report on analytical methods for measuring TMA and TMAO and attempt to critically synthesize and map the global functions of TMA and TMAO in a systems biology framework.
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