4.7 Article

NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering

Mahetab H. Amer et al.

Summary: The study demonstrates the potential of using microparticles as modulating moieties of osteogenic response through exploiting their architectural features. Cells cultured on topographically textured microparticles exhibit notably increased expression of osteogenic markers compared to conventional smooth microparticles, with significantly altered gene expression and metabolic profiles observed in vivo. This highlights how tailoring topographical design offers cell-instructive 3D microenvironments for manipulating stem cell fate without the use of exogenous osteoinductive factors.

BIOMATERIALS (2021)

Review Endocrinology & Metabolism

Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation

Annalisa Roberti et al.

Summary: NNMT acts as a key link between cellular metabolism and epigenetic gene regulation, playing a central role in various pathologies. Targeting NNMT pathways represents a current pharmaceutical challenge for treating a range of metabolic-related diseases and cancers.

MOLECULAR METABOLISM (2021)

Article Cell & Tissue Engineering

Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation

Jianjia Li et al.

Summary: This study conducted a dynamic proteomic analysis of osteogenic differentiation of hPDLSCs, revealing a regulatory mechanism and potential perspectives for periodontal regeneration research. The results indicated that oxidative phosphorylation and redox-sensitive signaling pathways play important roles in osteogenesis, with SOD2 identified as a key protein in the process.

STEM CELL RESEARCH & THERAPY (2021)

Article Multidisciplinary Sciences

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Tom Hodgkinson et al.

Summary: This study demonstrates the use of nanovibrational stimulation to induce osteogenic differentiation of mesenchymal stem cells without the need for exogenous growth factors. By identifying specific bioactive metabolites through this method, such as cholesterol sulfate and fludrocortisone acetate, the researchers were able to optimize metabolite potency by examining structure-function relationships with cytoskeletal contractility and cell stiffness as measures.

SCIENCE ADVANCES (2021)

Review Chemistry, Medicinal

Matrix Vesicles: Role in Bone Mineralization and Potential Use as Therapeutics

Sana Ansari et al.

Summary: MtVs, including phosphatases, calcium, and inorganic phosphate, play a crucial role in matrix mineralization and possess bone-targeting and osteo-inductive properties.

PHARMACEUTICALS (2021)

Article Cell Biology

SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Antagonizing DNMT1

Bo Jia et al.

Summary: The study reveals that SIRT6 physically interacts with DNMT1 protein, deacetylating and destabilizing it, leading to the activation of NOTCH1 and NOTCH2, which promotes the osteogenic differentiation of ADSCs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cell & Tissue Engineering

Metabolomic Applications in Stem Cell Research: a Review

Daniela S. C. Bispo et al.

Summary: This review describes the use of metabolomics to study stem cell characteristics and function, particularly focusing on developments in the past five years. The analysis covers various aspects of mesenchymal SC behavior, followed by pluripotent and neural SCs, with a few reports addressing other SC types, demonstrating the potential of metabolomics in understanding SC behavior.

STEM CELL REVIEWS AND REPORTS (2021)

Review Biotechnology & Applied Microbiology

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Luciano Vidal et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Lipidomics of mesenchymal stem cell differentiation

Camila Gonzaga da Silva et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2020)

Article Endocrinology & Metabolism

Mapping choline metabolites in normal and transformed cells

Irena Roci et al.

METABOLOMICS (2020)

Review Dentistry, Oral Surgery & Medicine

What is the function of osteocalcin?

Toshihisa Komori

JOURNAL OF ORAL BIOSCIENCES (2020)

Article Biochemistry & Molecular Biology

Multiomics Evaluation of Human Fat-Derived Mesenchymal Stem Cells on an Osteobiologic Nanocomposite

Austin Bow et al.

BIORESEARCH OPEN ACCESS (2020)

Review Cell Biology

How to influence the mesenchymal stem cells fate? Emerging role of ectoenzymes metabolizing nucleotides

Katarzyna Roszek et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2

Toshihisa Komori

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Nutrition & Dietetics

Role of Citrate in Pathophysiology and Medical Management of Bone Diseases

Donatella Granchi et al.

NUTRIENTS (2019)

Review Cell Biology

Adult Stem Cells for Bone Regeneration and Repair

Maria Rosa Iaquinta et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Biochemical Research Methods

Analytical techniques for metabolomic studies: a review

Karen Segers et al.

BIOANALYSIS (2019)

Article Cell & Tissue Engineering

YAP as a key regulator of adipo-osteogenic differentiation in human MSCs

Chanchao Lorthongpanich et al.

STEM CELL RESEARCH & THERAPY (2019)

Review Endocrinology & Metabolism

The Metabolic Microenvironment Steers Bone Tissue Regeneration

Julia Loeffler et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Article Cell & Tissue Engineering

Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison

Samih Mohamed-Ahmed et al.

STEM CELL RESEARCH & THERAPY (2018)

Review Endocrinology & Metabolism

The Role of the Immune Cells in Fracture Healing

Gurpreet S. Baht et al.

CURRENT OSTEOPOROSIS REPORTS (2018)

Article Biochemistry & Molecular Biology

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

Xiaojing Liu et al.

Article Biochemistry & Molecular Biology

Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation

Brianna H. Shares et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemical Research Methods

Combining Mass Spectrometry and NMR Improves Metabolite Detection and Annotation

Fatema Bhinderwala et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Review Biochemistry & Molecular Biology

Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth

Peng Li et al.

AMINO ACIDS (2018)

Article Medicine, Research & Experimental

Betaine promotes cell differentiation of human osteoblasts in primary culture

Isabella Villa et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Article Multidisciplinary Sciences

NMR Metabolomics for Stem Cell type discrimination

Franca Castiglione et al.

SCIENTIFIC REPORTS (2017)

Article Engineering, Biomedical

Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor

Penelope M. Tsimbouri et al.

NATURE BIOMEDICAL ENGINEERING (2017)

Article Chemistry, Multidisciplinary

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

Jemma N. Roberts et al.

ACS Nano (2016)

Article Biochemistry & Molecular Biology

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics

Annalaura Mastrangelo et al.

BIOCHEMICAL JOURNAL (2016)

Editorial Material Orthopedics

Multiple P-values and Bonferroni correction

J. Ranstam

OSTEOARTHRITIS AND CARTILAGE (2016)

Article Cell & Tissue Engineering

Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation

Laura C. Shum et al.

STEM CELLS AND DEVELOPMENT (2016)

Review Cell & Tissue Engineering

Aging, inflammation, stem cells, and bone healing

Emmanuel Gibon et al.

STEM CELL RESEARCH & THERAPY (2016)

Review Cell & Tissue Engineering

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

Fatemeh Atashi et al.

STEM CELLS AND DEVELOPMENT (2015)

Article Medicine, Research & Experimental

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling

Courtney M. Karner et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

Taurine promotes human mesenchymal stem cells to differentiate into osteoblast through the ERK pathway

Chenhui Zhou et al.

AMINO ACIDS (2014)

Review Endocrinology & Metabolism

Reflections on univariate and multivariate analysis of metabolomics data

Edoardo Saccenti et al.

METABOLOMICS (2014)

Article Chemistry, Multidisciplinary

Using Nanotopography and Metabolomics to Identify Biochemical Effectors of Multipotency

P. Monica Tsimbouri et al.

ACS NANO (2012)

Review Nursing

Effect size estimation: Methods and examples

Lut Berben et al.

INTERNATIONAL JOURNAL OF NURSING STUDIES (2012)

Review Cell & Tissue Engineering

Bone Tissue Engineering: Current Strategies and Techniques-Part II: Cell Types

Caroline Szpalski et al.

TISSUE ENGINEERING PART B-REVIEWS (2012)

Article Engineering, Biomedical

Skeletal stem cell physiology on functionally distinct titania nanotopographies

Laura E. McNamara et al.

BIOMATERIALS (2011)

Article Cell Biology

The Metabolism of Human Mesenchymal Stem Cells During Proliferation and Differentiation

Girish Pattappa et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

Article Chemistry, Physical

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

Rebecca J. McMurray et al.

NATURE MATERIALS (2011)

Article Biochemistry & Molecular Biology

Active creatine kinase is present in matrix vesicles isolated from femurs of chicken embryo: Implications for bone mineralization

Anna Sekrecka-Belniak et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Endocrinology & Metabolism

Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles

Pietro Ciancaglini et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Multidisciplinary Sciences

Strongly bound citrate stabilizes the apatite nanocrystals in bone

Y. -Y. Hu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Cell & Tissue Engineering

Human Mesenchymal Stem Cells Efficiently Manage Oxidative Stress

Araceli Valle-Prieto et al.

STEM CELLS AND DEVELOPMENT (2010)

Article Chemistry, Analytical

Analytical Approaches toward Successful Human Cell Metabolome Studies by NMR Spectroscopy

Iola F. Duarte et al.

ANALYTICAL CHEMISTRY (2009)

Review Biochemistry & Molecular Biology

Role of matrix vesicles in biomineralization

Ellis E. Golub

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Article Cell Biology

Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts

Isabel R. Orriss et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2009)

Article Clinical Neurology

Prospective study of iliac crest bone graft harvest site pain and morbidity

David H. Kim et al.

SPINE JOURNAL (2009)

Article Biochemical Research Methods

High-throughput tissue extraction protocol for NMR- and MS-based metabolomics

Huifeng Wu et al.

ANALYTICAL BIOCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

N-acetylcysteine stimulates osteoblastic differentiation of mouse calvarial cells

Ji Hae Jun et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Article Cell & Tissue Engineering

Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue

Linyi Peng et al.

STEM CELLS AND DEVELOPMENT (2008)

Review Biochemical Research Methods

Chemometrics in metabonomics

Johan Trygg et al.

JOURNAL OF PROTEOME RESEARCH (2007)

Article Biochemistry & Molecular Biology

HMDB: the human metabolome database

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Biochemistry & Molecular Biology

Human PHOSPH01 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities

SJ Roberts et al.

BIOCHEMICAL JOURNAL (2004)

Article Biochemistry & Molecular Biology

Upstream and downstream targets of RUNX proteins

F Otto et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2003)