Improvement in antibacterial activity of Poly Vinyl Pyrrolidone/Chitosan incorporated by graphene oxide NPs via laser ablation

Laser ablation was used to create novel nanocomposites of Chitosan-Poly (Vinyl Pyrrolidone) (PVP) blend incorporating graphene oxide nanoparticles (GONPs) to be utilized in microbial applications. The change in the structural, and optical properties of pure Chitosan-PVP after incorporated by graphene oxide have been investigated. XRD results confirmed the incorporation of GO into Chitosan/PVP blend and FT-IR results confirmed the interaction between Chitosan-PVP and GO NPs. UV data was confirmed that Chitosan/PVP/GO NPs after laser ablation time 10 min has lower band gap energy compared to other samples. The antimicrobial behavior of Chitosan/PVP/GO NPs at two times of laser ablation (5 min and 10 min) were performed against E. coli, P. aeruginosa, S. aureus, B. subtilis, and C. Albicans. The antimicrobial activity shows enhancement in the inhibition zones, it was enhanced from 5 +/- 0.98 to 13 +/- 0.72 for E. coli, 6 +/- 0.56to 15 +/- 0.84 for P. aeruginosa, 7 +/- 0.73 to 17 +/- 0.26 for S. aureus, 4 +/- 0.89 to 15 +/- .07 for B. subtilis, and 3 +/- 0.54 to 8 +/- 0.76 for C. Albicans. Chitosan/PVP/GO NPs significantly improve antimicrobial effects. The prepared compositions could be suggested after further study to be applied in microbial applications.

Automated summary

Laser ablation was used to create novel nanocomposites of Chitosan-Poly (Vinyl Pyrrolidone) blend incorporating graphene oxide nanoparticles (GONPs) for microbial applications. The antimicrobial behavior of the prepared Chitosan/PVP/GO NPs was significantly enhanced, showing increased inhibition zones against various bacteria and fungi. Further study could lead to their potential application in microbial settings.