Journal
IMMUNOLOGY
Volume 149, Issue 4, Pages 423-431Publisher
WILEY
DOI: 10.1111/imm.12659
Keywords
ATP citrate lyase; citrate pathway; Down syndrome; inflammation; mitochondrial citrate carrier; oxidative stress
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Funding
- Area Science Park [J41H09000010007]
- Ministero dell'Universita e della Ricerca (MIUR)
- Universities of Basilicata and Bari 'Aldo Moro'
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Inflammatory conditions and oxidative stress have a crucial role in Down syndrome (DS). Emerging studies have also reported an altered lipid profile in the early stages of DS. Our previous works demonstrate that citrate pathway activation is required for oxygen radical production during inflammation. Here, we find up-regulation of the citrate pathway and down-regulation of carnitine/acylcarnitine carrier and carnitine palmitoyl-transferase 1 genes in cells from children with DS. Interestingly, when the citrate pathway is inhibited, we observe a reduction in oxygen radicals as well as in lipid peroxidation levels. Our preliminary findings provide evidence for a citrate pathway dysregulation, which could be related to some phenotypic traits of people with DS.
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