Green synthesis of Nd substituted Co-Ni nanospinel ferrites: a structural, magnetic, and antibacterial/anticancer investigation

Co0.5Ni0.5Nd0.02Fe1.98O4 (CoNiNdFO) nanospinel ferrites (NSFs) with and without plant extracts (cardamom seeds, date fruits, flaxseed, tragacanth gum, lavender seeds, and moringa) were prepared using a sol-gel approach. The impact of utilizing different plant extracts on the structural, morphological, and magnetic features of the final products is discussed. Room temperature (300 K) magnetization findings illustrate superparamagnetic (SPM) characteristics for the products synthesized using the cardamom and moringa plant extracts mediated sol-gel approach, whereas the remaining products display ferromagnetic characteristics. On the other hand, lower temperature (10 K) magnetization curves indicate that all the prepared samples exhibit ferromagnetic (FM) behavior. It was found that the magnetic parameters vary greatly with the synthesis approach, plant extract solution, distribution of cations, morphology, and size of NSFs, spin canting, etc. The obtained results indicate that the different synthesis approaches employed in the present investigation are simple, inexpensive, and eco-friendly, and could lead to obtaining interesting magnetic properties. The biological applications of these NSFs were examined. The impact of NSFs with and without cardamom and moringa extracts on human colorectal carcinoma cells (HCT-116) and cervical cancer cells (HeLa) was assessed by checking cell viability using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and 4 ',6-diamidino-2-phenylindole (DAPI) staining methods. The treatments of NSFs with and without cardamom and moringa extracts decreased cancer cell viability. We calculated the inhibitory concentration (IC50) values for NSFs with and without cardamom and moringa extracts. The treatment of NSFs with and without cardamom and moringa extracts on HCT-116 cells and HeLa cells induced a significant decrease in cancer viability, as revealed by MTT assay. The treatment of NSFs with and without cardamom and moringa extracts caused a noteworthy decrease in colon cancer cells as the number of DAPI stained cells was found to be less in the treated cells. The evaluation of the anti-staphylococcal activity of NSFs with and without cardamom and moringa extracts via the colony-forming unit (CFU) method showed growth inhibition of S. aureus. It was observed that the nanoparticles synthesized via green synthesis had a marked cell count reduction, proving the microbial toxicity of nanoparticles to S. aureus.

Automated summary

In this study, nanospinel ferrites (NSFs) containing different plant extracts were synthesized using a sol-gel approach. The impact of plant extracts on the structural, morphological, and magnetic features of the final products was discussed. The results showed that the synthesis method, plant extract solution, distribution of cations, morphology, and size of NSFs significantly influenced the magnetic properties. The NSFs synthesized using cardamom and moringa plant extracts exhibited superparamagnetic behavior at room temperature. Furthermore, the NSFs containing cardamom and moringa extracts demonstrated anti-cancer activity against colorectal carcinoma cells and cervical cancer cells, as well as antimicrobial activity against Staphylococcus aureus.